《从袁隆平把论文写在水稻田里想到的......》

2025-04-04 12:48阅读：

http://blog.sina.cn/dpool/blog/u/1230335553

《从袁隆平把论文写在水稻田里想到的......》

黄连素老药新用，並非如今才有的曾经荒芜之地病人。国内外许多学者就其降脂、减重、降糖效应长期默默耕耘。几十年来临床应用于糖尿病及其并发症防治的报告並不少，且大有越来越多之势。其实，寻根究底老祖宗早在公元1400多年前的东汉《神农本草经》，魏晋时《名医别录》中就有黄连“主消渴”的记载。不过到了现代，随着科技发展找到了其降糖精准成分小檗碱(黄连素)罢了。
现代重磅临床应用于糖尿病及并发症研究文献可查的，可追溯到差不多快40年前的中国中西医结合杂志就有了有份量的黄连素治疗糖尿病的报告。至于，国内外黄连素的基础研究就更早，更多，不知其数了。
直至2008年上海交大瑞金、新华医院和二军大长海医院及复旦闵中心医院等四家医院开展以二甲双胍为对照组的多中心双盲对照的临床研究，文章发表于美国临床内分泌代谢杂志。并作了黄连素治疗糖尿病和血脂异常是有效和安全的结论。
此研究成果文章中英文摘要：
《Treat

ment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine 》
（The Journal of Clinical Endocrinology & Metabolism, Volume 93, Issue 7, 1 July 2008, Pages 2559–2565,）
【Abstract】
Context: Berberine, a natural plant alkaloid, is usually used as an antibiotic drug. The potential glucose-lowering effect of berberine was noted when it was used for diarrhea in diabetic patients. In vitro and in vivo studies have then showed its effects on hyperglycemia and dyslipidemia.
【Objective:】
The objective of the study was to evaluate the efficacy and safety of berberine in the treatment of type 2 diabetic patients with dyslipidemia.
【Design: 】
One hundred sixteen patients with type 2 diabetes and dyslipidemia were randomly allocated to receive berberine (1.0 g daily) and the placebo for 3 months. The primary outcomes were changes in plasma glucose and serum lipid concentrations. Glucose disposal rate (GDR) was measured using a hyperinsulinemic euglycemic clamp to assess insulin sensitivity.
【Results: 】
In the berberine group, fasting and postload plasma glucose decreased from 7.0 ± 0.8 to 5.6 ± 0.9 and from 12.0 ± 2.7 to 8.9 ± 2.8 mM/liter, HbA1c from 7.5 ± 1.0% to 6.6 ± 0.7%, triglyceride from 2.51 ± 2.04 to 1.61 ± 1.10 mM/liter, total cholesterol from 5.31 ± 0.98 to 4.35 ± 0.96 mM/liter, and low-density lipoprotein-cholesterol from 3.23 ± 0.81 to 2.55 ± 0.77 mM/liter, with all parameters differing from placebo significantly (P < 0.0001, P < 0.0001, P < 0.0001, P = 0.001, P < 0.0001, and P <0.0001, respectively). The glucose disposal rate was increased after berberine treatment (P = 0.037), although no significant change was found between berberine and placebo groups (P = 0.063). Mild to moderate constipation was observed in five participants in the berberine group.
【Conclusions:】
Berberine is effective and safe in the treatment of type 2 diabetes and dyslipidemia.
中文译文：
《标题：》小檗碱治疗2型糖尿病和血脂异常的药理作用
《临床内分泌学与代谢杂志》（The Journal of Clinical Endocrinology & Metabolism）卷号：93期号：7日期：2008年7月1日页码：2559–2565
【摘要】

【背景】小檗碱是一种天然植物生物碱，通常用作抗生素。在用于治疗糖尿病患者的腹泻时，人们注意到了小檗碱潜在的降血糖作用。随后的体外和体内研究显示了其对高血糖和血脂异常的影响。
【目的】本研究旨在评估小檗碱治疗伴有血脂异常的2型糖尿病患者的疗效和安全性。
【设计】116名患有2型糖尿病和血脂异常的患者随机分配接受小檗碱（每日1.0克）和安慰剂治疗3个月。主要结果是血浆葡萄糖和血清脂质浓度的变化。通过高胰岛素正常血糖钳夹技术测量葡萄糖处置率（GDR），以评估胰岛素敏感性。
【结果】在小檗碱组中，
空腹血浆葡萄糖从7.0 ± 0.8降至5.6 ± 0.9；

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